Rifampicin

Rifampicin is active against gram-positive bacteria but less active against gram-negative bac-teria. It interferes with the synthesis of nucleic acids by inhibiting DNA dependent RNA polymerase. Resistance to rifampicin can develop rapidly. The degree of resistance varies depending on the site of mutation in the RNA polymerase.

Storage condition

• Store dry at 2-8 °C
• Soluble in dilute acid solution

Hazard statements

• H302 Harmful if swallowed
• H315 Causes skin irritation
• H319 Causes serious eye irritation
• H335 May cause respiratory irritation
• H361 Suspected of damaging fertility or the unborn child
• H362 May cause harm to breast-fed children

Precautionary statements

• P202 Do not handle until all safety precautions have been read and understood
• P261 Avoid breathing dust/fume/gas/mist/vapours/spray
• P263 Avoid contact during pregnancy/while nursing
• P280 Wear protective gloves/protective clothing/eye protection/face protection
• P305 IF IN EYES:
• P308 IF exposed or concerned:
• P313 Get medical advice/attention
• P351 Rinse continuously with water for several minutes